SYK and infection: In WT macrophages, infection with WT hyphae led to an increase in p-Syk levels at 20 min post-infection, whereas infection with the als1Δ/Δals3Δ/Δ or als1Δ/Δals3S170Y strains resulted in less Syk activation (Fig. 6c and Supplementary Fig. 6c).