Six regulons were upregulated in the CLL phase (TCF4, JUND, ENO1, BCLAF1, SPIB, and SMARCB1), and 4 in the RS-like phase (ZNF274, JUN, FLI1, and BACH2) (Fig. 5E, Supplementary Fig. 4C). This evidence concerns the gene JUN and B-cell chronic lymphocytic leukemia.