In vitro, we found that SOAT1 decreased the expression of epithelium protein marker (E-cadherin and Occludin) and increased the expression of mesenchymal protein (Vimentin, Twist1, N-cadherin, Snail1, Slug, and Fibronectin), promoting invasion and migration of HCC cells. The gene discussed is OCLN; the disease is hepatocellular carcinoma.