Similarly, the mitotic checkpoint serine/threonine kinase BUB1—which interacts with EGFR, BTK, ERBB2, LYN, and PTK6—was strongly activated in HCT-15 cells up to 24 h, suggesting that resistance/survival of this CRC cell line could be attributed, to some extent, to its increased signaling activity72. Here, BTK is linked to colorectal carcinoma.