Folic acid can inhibit ERK1/2/NOX4/ROS pathway to reduce peroxide production, enhance antioxidant enzyme activity to attenuate oxidative stress and inflammation, and thus play a protective role on stroke.35 More importantly, folic acid may alleviate thromboxane A2 release and clotting factor expression by decreasing tHcy, thereby reducing platelet activation and thrombosis, and ultimately preventing stroke. The gene discussed is MAPK3; the disease is stroke disorder.