Huang et al. showed that hypertensive patients with the MTHFR C677T gene mutation caused an increased incidence of stroke due to folic acid metabolism disorder, however they did not benefit from folic acid treatment.5 The proportion of TT homozygous genotype population in Europe and the United States is about 11.1 to 32.2%.6,7 The distribution of the MTHFR 677 CC, CT and TT genotype in a European population was reported by Spence et al. as 40.4%, 46.6% and 13%, respectively.8 The prevalence of the Chinese hypertensive MTHFR 677 TT genotype adults is much larger than other countries. The gene discussed is MTHFR; the disease is Stroke.