Second, the study population consisted of Chinese adults with hypertension, with a higher prevalence of TT genotypes compared to Western populations (25% in China compared to 10 to 12% in America).7,9 Third, our study is the first to evaluate folic acid benefit situation on stroke prevention by performing a comprehensive analysis of platelet activation parameters and the MTHFR C677T genotype. Here, MTHFR is linked to stroke disorder.