KLRK1 and infection: oHSVs, including G207, have demonstrated increased TILs and improved pro-inflammatory signatures following viral administration in patients with GBM,35 36 with observations made in post-treatment biopsies taken within a week following oHSV treatment,35 37 but even as little as 2 days post-G207 treatment.9 Given the kinetics of NKG2D BiTE activation following infection of GBM cells with G207-NKG2D BiTE virus takes around 72 hours, this timing of TIL infiltration could coincide with the accumulation of NKG2D BiTE to therapeutically effective doses.