The analysis of CD4+ and CD8+ T-cell subset populations indicated higher IFN-γ production (>2 log10 IMFI) by the CD4+Tem subset in individuals with ocular toxoplasmosis, compared with uninfected and asymptomatic individuals, in response to either TE or NP/TE at 0.3 μg/ml stimuli. Here, CD4 is linked to ocular toxoplasmosis.