Several microglia‐associated N‐glycoproteins are hyperglycosylated in AD, including Stabilin‐1, Intercellular Adhesion Molecule 1 (ICAM‐1), the NADPH oxidase (NOX2) component cytochrome b‐245, clusterin [20].Taken as a whole, our data supports an increase in N‐sialylation may potentially modulate microglia functions within the plaque environment. The gene discussed is ICAM1; the disease is Alzheimer disease.