MAPT and Alzheimer disease: The goal of the current study was to (1) characterize histology techniques to visualization the sialylation landscape in human brain tissue; (2) determine where specific forms of N‐ and O‐linked SA modifications are located in AD brains relative to Aβ plaques, microglia, and phosphorylated tau pathology; and (3) utilize brain regions vulnerable to AD pathology to better determine spatiotemporal distribution of sialylation patterns.