However, in this study, we could not detect growth suppression by SMYD5 knockdown in NCI-H1299 and H1703 cell lines (data not shown), but SMYD5 knockdown reduced cell migration, invasion, and wound healing rates in lung cancer cell lines, implying that the function of SMYD5 in lung cancer is mainly involved in lung cancer metastasis. The gene discussed is SMYD5; the disease is lung carcinoma.