In cancers, overexpression of SH2B3 reduced the invasion ability in HCT116 and HT29 colon cancer cell lines (Pan et al., 2020) and regulation of the epithelial-mesenchymal transition (EMT) process by controlling the janus tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) and Src homology region 2 domain-containing phosphatase-2 (SHP2)/growth factor receptor-bound protein 2 (Grb2) pathways in lung cancer (Wang et al., 2022). This evidence concerns the gene STAT3 and malignant colon neoplasm.