Additionally, Stender et al. (2012) showed that overexpression of SMYD5 led to an increase in the amount of H4K20 trimethylation, while the levels of other marks, such as H3K36me3, H3K27me3, H3K9me3, and H3K4me3, remained unchanged. Thus, in this study, to identify metastasis-regulated genes in lung cancer, we focused on genes upregulated by SMYD5 knockdown. This evidence concerns the gene SMYD5 and lung cancer.