Several recent studies applied GWAS to NASH and identified the missense variant p.A165T of the mitochondrial amidoxime-reducing component 1 (mARC1, encoded by the MTARC1 gene) as protective from both alcoholic and nonalcoholic cirrhosis (1, 10, 11). Here, MTARC1 is linked to metabolic dysfunction-associated steatohepatitis.