Notably, it has emerged that there is a crosstalk between the neurotrophin pathway, particularly the nerve growth factor (NGF)-NTRK1 axes, and GPCR signaling mediated by either (nor)adrenaline-ADRB2 in pancreatic cancer,19 or acetylcholine-CHRM1 and CHRM3 in gastric cancer.20 The gene discussed is NGF; the disease is gastric cancer.