APC and familial pancreatic carcinoma: Several other pathways are exclusively enriched in specific cancer tissues; for example, glucagon-like peptide-1 (GLP1) regulates insulin secretion, synthesis of PGs and TXs, and acetylcholine regulates insulin secretion are hallmarks of pancreatic cancer and might contribute to reinforcing the known role of the Gs-PKA signaling axis in this cancer type.26