Certain receptors are instead invariably associated with poorer survival, such as OXTR, ADORA2B, GPR3, FZD6, GPRC5A, and LPAR3. We also found a large prevalence of associations between GPCR-peptide ligand precursor expression and lower survival of patients, with 67.2% of the significant instances across cancers. Here, ADORA2B is linked to cancer.