CXCR2 and neoplasm: Our map also revealed slightly different co-regulation patterns for chemokine axes entailing different types of ligand action on the receptors, such as the known CXCR3 agonist CXCL11, which also antagonizes CCR3. 37The known tumor-promoting CXCR2 is found co-downregulated together with CXCL2 in liver cancer (iCluster2 subtype) and with PPBP, the precursor of CXCL7, in lung (LUAD.3 subtype).