Strikingly, we found that 73 out of 79 cancer subtypes (92.4%) are characterized by a prevalence of concordant (i.e., having the same log2-fold change (LFC) directionality) vs. discordant (i.e., having opposite LFC directionality) regulation of GPCR axes, suggesting tight correlated expression of the components of the same receptor-ligand axis (Figure S4). The gene discussed is LGR6; the disease is cancer.