Cluster 2 contains instead receptor-ligand axes that are more frequently concordantly downregulated in cancer subtypes, although several of these might still be concordantly upregulated in specific subtypes (e.g., CXCR2, EDNRB, FFPR2, or LGR6, GALR2, and UTS2R; Figure 2A). This evidence concerns the gene EDNRB and cancer.