For example, in head and neck cancers, we found significant correlation of higher survival and higher expression of the SSTR2-SST (Figure S10A), RXFP3-INSL5, and RXFP1-RLN3 signaling axis, which all share similar coupling profiles (e.g., Gq/11, particularly GNA14, as well as Gi/o; Figure S11). The gene discussed is RLN3; the disease is head and neck cancer.