PGR and breast benign neoplasm: (all p-values ≤ 2.47E–09; Figure 3a, Table S5), Similarly, methylation levels were reduced in both PR-positive and PR-negative BC compared with benign breast tumours, and the reduction was more pronounced in PR-negative BC (all p-values ≤ 2.49E–07; Figure 3b, Table S6).