The current study aims to examine the effectiveness of liposomal loaded dexamethasone, doxorubicin, and turmeric in treating CRISPR-Cas9, long non-coding RNAs, as well as Lnc-RNAs generated in rat models of prostate cancer in addition to some related molecular pathways including AKT, PI3K and GSK-3. This evidence concerns the gene PIK3CG and prostate carcinoma.