ASCL1 and lung cancer: Upregulation of miR-375 was reported to be a prerequisite for the induction of neuroendocrine features via the transcription factor achaete-scute complex homolog 1 (ASCL1), which is a basic-helix-loop-helix (bHLH) protein that is expressed in normal pulmonary neuroendocrine cells and in lung cancers with neuroendocrine features [40–42].