Among 1,049 participants admitted to an ICU due to infection during the study period, 247 (23.6%) were women; the median age at admission was 76 years (IQR 71–81); 330 (31.5%) were never smokers, 381 (36.3%) former smokers, and 338 (32.2%) current smokers at baseline in 1997; the median SAPS3 was 67 (IQR 59–76); and 379 (36.1%) were treated with invasive mechanical ventilation (S1 Table). This evidence concerns the gene PPP6R3 and infection.