Analysis of differential gene expression changes as well as PEAs, specifically performed within the T cell data set, again identified IFN signaling as the top regulated pathway and identified different IFN-induced genes that were downregulated in patients with SLE upon CD19 CAR T cell therapy in different T cell subsets (Figure 2, D–F). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.