MKI67 and colitis: Ire1αΔRorcRag1–/– mice developed more severe acute DSS colitis, as indicated by weight loss, clinical score, shortening of colon length, histology score, goblet cell loss (alcian blue/PAS), and epithelial cell proliferation (Ki67) (Supplemental Figure 11), corroborating the phenotype of the Ire1αΔRorc mice.