Paralleling our observations in human COPD and emphysema, mice with CS- or nCB-induced emphysema exhibited reduced expression levels of pri-Mirlet7b/c2 and pri-Mirlet7a1/f1/d transcripts in the lung and from isolated lung CD4+ and CD8+ T cells (Figure 1F–H). Here, CD8A is linked to chronic obstructive pulmonary disease.