LIN28B and chronic obstructive pulmonary disease: We and others explored the consequence of loss of Mirlet7 expression/activity with synthetic oligonucleotides, sponges, lentiviral antisense knockdown, or via ectopic delivery of Lin28b (Polikepahad et al., 2010; Viswanathan et al., 2008; Piskounova et al., 2011), but studies pinpointing the role of individual Mirlet7 clusters as potential drivers of lung inflammation and COPD within T cells remained elusive.