Although using f-Hb concentrations could offer a straightforward method to personalize screening, several studies have suggested incorporating additional individual characteristics—such as family history, body mass index, and smoking—as risk scores in conjunction with FIT to enhance the precision of cancer detection.26,27 There are already systems in place where information such as sex, age, and the quantitative FIT result is registered in existing databases for all screening participants. The gene discussed is GSTM1; the disease is cancer.