PIK3C2A and rhabdomyolysis: The characteristic triad of rhabdomyolysis symptoms are muscle pain, weakness and red to brown colored urine due to high levels of myoglobin, although over half of patients do not have all of these specific symptoms.5 The standard diagnostic criteria for exertional rhabdomyolysis are elevated serum creatine phosphokinase (CPK) levels indicating myonecrosis (usually defined as CPK level of at least 5 times the upper limit of normal) following recent exercise.2,3,6