HK2 and esophageal squamous cell carcinoma: In addition to that, cell experiments observed that silencing RMRP suppressed proliferation rates, elevated apoptosis rates, lowered glucose consumption, lactic acid production, and ATP levels, and inhibited HK2 and PKM2 protein expression, providing evidence that RMRP prevented proliferative and glycolytic activities and induced apoptosis during ESCC cell growth.