Fragmentation of the neuronal Golgi apparatus is a well described pathological characteristic associated with ALS [28, 83, 98–100] that has been detected in sporadic ALS patient motor neurons [100], in animal disease models based on mutant SOD1 [101, 102] or expressing mutant TDP-43M337V [103], and in cells expressing mutant forms of SOD1 or FUS [104]. Here, SOD1 is linked to amyotrophic lateral sclerosis.