MTOR and neoplasm: Moreover, the “ADIPOGENESIS” pathway, which was correlated with unfavorable tumor microenvironment and worse survival, and the “P13/AKT/mTOR” pathway, which has been proved to have a strong relationship with proliferation, migration, and invasion, were also activated in cluster 2 (Gasparri et al. 2018; Oshi et al. 2021).