NFKB1 and Cachexia: Systemic inflammation triggers muscle atrophy associated with cachexia via activation of muscle nuclear factor-kappa B (NF-κB) signaling, leading to ubiquitin proteasome system (UPS)-mediated proteolysis (Argilés et al. 2005; Cai et al. 2004; Camps et al. 2006; Fearon et al. 2011).