CD8A and hemophagocytic syndrome: Mice with defects in the corresponding genes do not develop HLH spontaneously (Jordan et al., 2004; Crozat et al., 2007; Kogl et al., 2013; Sepulveda et al., 2013; Jessen et al., 2011; Pachlopnik Schmid et al., 2008), but infection with lymphocytic choriomeningitis virus (LCMV) induces the complete clinical manifestation of HLH with CD8 T cells and IFNγ as the main drivers of the pathology (Jordan et al., 2004; Pachlopnik Schmid et al., 2009; Kogl et al., 2013; Rood et al., 2016).