These results imply that the miRNA138-5p-modulating GPR124, NLRP3 inflammasome, and LIF–STAT3 signaling in the decidual endometrium constitute a potential therapeutic approach for enhancing embryo implantation in the treatment of infertility but also would provide important insights into the mechanism of embryo implantation and decidual programming of human pregnancy. This evidence concerns the gene ADGRA2 and Infertility.