STAT3 and Infertility: These results imply that the miRNA138-5p-modulating GPR124, NLRP3 inflammasome, and LIF–STAT3 signaling in the decidual endometrium constitute a potential therapeutic approach for enhancing embryo implantation in the treatment of infertility but also would provide important insights into the mechanism of embryo implantation and decidual programming of human pregnancy.