CDH1 and posterior cortical atrophy: In case of Claudin-7, its downregulation was reported to be connected with more aggressive PCa,62–65 similarly, it was shown that E-cadherin loss can occur already in very early stages of benign hyperplasia.66 When Claudin-7 loss correlated with E-cadherin, this led to a more invasive phenotype in esophageal squamous carcinoma cells.67 In case of DU145 sEVs applied to the SSGB model, there was a slight decrease of Claudin-7 protein expression in the SSGB model after administration of H sEVs (0,67 ± 0,16) and to a lesser extent after N sEV (0,84 ± 0,08) treatment (Figure 5).