C9orf72 and amyotrophic lateral sclerosis: There is a strong link between miR-16-5p and ALS in the literature, as we and others have shown that this miRNA is downregulated in the blood (Liguori et al., 2018; Joilin et al., 2020) and cerebrospinal fluid (Waller et al., 2018) of patients with sporadic ALS, as well as in fibroblasts from patients with C9orf72-related ALS (Hur et al., 2023).