However, since the HIV-1-induced hematopoietic inhibition that is influenced by the CD4+ T-cells is indirect, the CD34+ HSPC-intrinsic-miRNAs may not be perturbed in order to self-regulate CD34+ intracellular functions that determine their own cell-fate, until the “arrival” of the abnormally modulated miR-15a and miR-24 at the site of CD34+ cells, following HIV infection. The gene discussed is CD4; the disease is HIV infectious disease.