Based on our published results (Padmanabhan et al., 2020), we hypothesize that upon HIV-1 infection of the CD4+ thymocytes, the observed differential regulation of miR-15a and miR-24 that occurs causes abnormal post-transcriptional regulation of specific HOX gene-encoded transcriptomes (Koka and Ramdass, 2023). This evidence concerns the gene CD4 and HIV-1 infection.