Previous study (Boumba et al., 1995; Mavragani, 2017) reported that IL-6, IL-8, IL-10, and TNF-α may be involved in the occurrence and development of ILD in patients with pSS, suggesting that the occurrence of pSS-ILD is closely related to the inflammatory response and needs clinical attention. This evidence concerns the gene CXCL8 and peeling skin syndrome.