In addition, among all pSS patients, cytokines were measured and analyzed in 222 patients showed that IL-6 was significantly higher in the pSS-ILD group than in the pSS-non-ILD group (p < 0.05), while no statistically significant differences between the remaining cytokines in the two groups (p > 0.05) (Table 1). This evidence concerns the gene IL6 and interstitial lung disease.