Immunohistochemical analysis demonstrated reduced proliferation (Ki-67 positive) and increased apoptosis (terminal deoxynucleotidyl transferase dUTP nick end labeling [TUNEL] positive) signals in the tumor cells of the Oxa@HMI hydrogel treatment group, further substantiating the efficacy of this treatment approach in promoting tumor cell apoptosis and inhibiting tumor growth. Here, MKI67 is linked to neoplasm.