Tumor tissues from mice treated with inulin showed upregulation of ID2 and IL-12 receptors (Fig. 8B), in tumor tissue, indicating that the inulin hydrogel matrix in Oxa@HMI hydrogel can be degraded by probiotics within tumor tissue to produce butyric acid, which induced CD8+ T cells to express more ID2 and IL-12 receptors for immune response activation. The gene discussed is ID2; the disease is neoplasm.