ESR1 and ovarian carcinoma: The observation that injected LNPs accumulate particularly in the ovaries and bone marrow [38] could better explain our findings of excess mortalities from ovarian cancer and leukemia in 2022. According to an analysis of scientific literature about sex hormone receptors in head and neck squamous cell carcinoma (HNSCC), ERα plays various roles in the biopathology of HNSCC, particularly oropharyngeal cancer.