To validate these data, LOH analysis was performed on the tumor and normal tissues of the patient using three dinucleotide microsatellite repeats located near the FH locus (1q43, GRCh37/hg19), D1S304, D1S204, and D1S321 (1q43), as well as two more distant markers, D1S235 (1q42.3) and D1S423 (1q44) (Supplementary Figure S6). Here, FH is linked to neoplasm.