Among 46 patients with PRD (Figure 3C), 25 (54.35%) exhibited a gradually increasing trend of TgAb over time, 21 (45.65%) had decreasing TgAb levels, five of whom (10.87%) had TgAb levels below 40 IU/mL at the latest visit, without any significant increase in Tg. The gene discussed is TG; the disease is X-linked retinal dysplasia.