Following adjustments for various factors such as sex, ethnicity, age, BMI, Hb, Scr, APACHE-IV score, ARF, AF, ACS, CHF, CKD, COPD, diabetes mellitus, GB, hypertension, sepsis, anti-platelet, anticoagulant, glucocorticoid, carbapenems, cephalosporins, vancomycin, and mechanical ventilation, a significant nonlinear association emerged (Log-likelihood ratio test p < 0.0001). This evidence concerns the gene GSTM1 and chronic kidney disease.