Based on the results of the correlation analysis and the clinical significance, we adjusted the model with various covariates (age, gender, ethnicity, education, family income to-poverty threshold ratio, alcohol consumption, smoking status, BMI, weight, TG, TC, LDL-C, HDL-C, insulin, HbA1c, HOMA-IR, HOMA-IS, hs-CRP, ALT, AST, GGT, ALP, total bilirubin, blood cobalt, total calcium, urine albumin, eGFR, hypertension, diabetes, hepatitis B, hepatitis C, autoimmune hepatitis, and LSM). The gene discussed is INS; the disease is autoimmune hepatitis.