Moreover, Cr supplementation increased the p-IRS-1, GLUT2, and GLUT4 expression in the liver of various animal models of metabolic disorders, such as NAFLD, obesity, T2DM and metabolic syndrome, and thus lowering the hepatic TG levels of these models (23–27). Here, SLC2A4 is linked to obesity due to melanocortin 4 receptor deficiency.