Cr supplementation decreased the expression of liver nuclear factor kappa-B (NF-κB) p65, and lowered plasma levels of C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1), and intercellular cell adhesion molecule-1 (ICAM-1) in animal models of obesity, metabolic syndrome and T2DM. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.