FASN and metabolic dysfunction-associated steatohepatitis: In animal models of NAFLD and non-alcoholic fatty liver hepatitis (NASH), Cr downregulated the mRNA expression of diacylglycerolacyltransferase (DGAT)-1, DGAT-2, and fatty acid synthase (FASN), while suppressed protein expression of perilipin-2 (PLIN-2), consequently lessening the storage of TG in liver tissue (28).