In Kunming mice with metabolic syndrome, Cr supplementation promoted cholesterol transport and metabolism by upregulating the mRNA expression of apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR) and suppressed cholesterol synthesis by upregulating cytochrome P450 7A1 (CYP7A1) mRNA expression (32, 33). Here, APOE is linked to metabolic syndrome.