It has also validated that stomatin‐like protein 2 (SLP2), which is upregulated by METTL3 and YTHDF1, binds to the C‐terminal of c‐Jun N‐terminal Kinase 2 (JNK2) to increase JNK2 levels and subsequently enhance SREBP1 activity, thereby facilitating de novo lipogenesis in HCC. This evidence concerns the gene YTHDF1 and hepatocellular carcinoma.