Recent evidence has shed light on the role of YTHDF2 in accelerating the mRNA degradation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) and the prostate‐specific homeobox gene NKX3−1 and the consequent activation of Akt This acceleration occurs via METTL3‐mediated m6A‐dependent mechanisms and significantly enhances tumor growth and metastasis in prostate cancer (PCa). This evidence concerns the gene LHPP and neoplasm.