Recent evidence has shed light on the role of YTHDF2 in accelerating the mRNA degradation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) and the prostate‐specific homeobox gene NKX3−1 and the consequent activation of Akt This acceleration occurs via METTL3‐mediated m6A‐dependent mechanisms and significantly enhances tumor growth and metastasis in prostate cancer (PCa). The gene discussed is AKT1; the disease is neoplasm.