METTL1 and head and neck squamous cell carcinoma: Additionally, in the progression of head and neck squamous cell carcinoma (HNSCC), the upregulation of the METTL1/WDR4 complex enhances the translation of oncogenic transcripts associated with the PI3K/AKT/mTOR signaling pathway, leading to alterations in the immune landscape and subsequent malignant development of HNSCC.193