Upregulated ALKBH3 has been found to significantly elevate the expression of downstream molecules, including NAD(P)H oxidase‐2 (NOX‐2) and TNF‐like weak inducer of apoptosis (Tweak), in urothelial carcinoma UMUC2 and UMUC3 cells, thereby inducing the accelerated cell cycle and angiogenesis in the development of urothelial carcinoma.200. This evidence concerns the gene CYBB and urothelial carcinoma.