The upregulation of METTL5 and TRMT112 expression in HCC samples is positively correlated with poor prognosis and mediates 18S rRNA m6A modification, thereby facilitating de novo lipogenesis via the overexpression of the acyl‐CoA synthetase long‐chain family (ACSL) in HCC cells.404. Here, METTL5 is linked to hepatocellular carcinoma.