And investigation of clinical human samples has revealed that the m6A demethylase ALKBH5 upregulates the expression of ubiquitin protein ligase E3 component N‐recognin 7 (UBR7), which is a negative regulator of glycolysis, and activates the kelch‐like ECH‐associated protein 1 (Keap1)/nuclear factor erythroid 2‐related factor 2 (Nrf2)/BTB domain and CNC homolog 1(Bach1)/HK2 pathway, thereby attenuating aerobic glycolysis in HCC.368. The gene discussed is UBR7; the disease is hepatocellular carcinoma.