Mutations in oncogenes, suppressor genes, and certain metabolic genes, such as MYC, RAS, p53, PTEN, EGFR, HIF‐1, isocitrate dehydrogenase (IDH) 1/2, and fumarate hydratase (FH), actuate diverse metabolic phenotypes and subsequently aberrantly change the tumor microenvironment (TME).209, 218, 219, 220. The gene discussed is MYC; the disease is neoplasm.