Given the pivotal role of T‐cells in OLP development, particularly CD8 tissue‐resident memory T‐cells that secrete cytokines promoting OLP erosion,25 as well as the induction of oral lesions by activated CD4+ T‐cell clones,19 and DCs are important antigen‐presenting cells, play a role in the development of the majority of autoimmune illnesses during the immune response, we hypothesized that PA28γ in OLP may indeed influence DCs and subsequent T‐cell immune responses, thereby impacting disease progression. This evidence concerns the gene PSME3 and oral lichen planus.