found that fulminant T1D (a subtype of T1D characterized by a drastic onset of hyperglycemia and all pancreatic β cell destruction)-iPSCs-derived insulin-producing cells were susceptible and have the overexpression of apoptosis associated genes to co-stimulation of TNF-α, IL-1β, and IFN-γ. The gene discussed is TNF; the disease is type 1 diabetes mellitus.