CTLA4 and autoimmune disease: Non-HLA risk genes such as tumor necrosis factor (TNF) receptor superfamily member 1A (10), interleukin (IL)-2 receptor subunit α (IL-2RA) (11), SH2B adaptor protein 3 (12), and Cytotoxic T-lymphocyte Associated Antigen 4 (CTLA4) (13), are also involved in autoimmune diseases.