also observed the iPSCs-derived MSCs promoted mucosal healing by increasing the proliferation of intestinal epithelial stem cells (Lgr5+ and CD44+ cells) in the trinitrobenzene sulfonate (TNBS) and DSS-induced mice colitis model via secreting TNF-α-stimulated gene-6 (TSG-6), which has been proved to have potential immunoregulatory capacity and tissue protective effects in the disease models such as myocardial infarction, arthritis, atherosclerosis, wound healing and fibrosis (Table 3) (93, 97). Here, CD44 is linked to colitis.