Several included studies have demonstrated that administering whichever of 5-aminosalicylic acid, thiopurines, glucocorticoids, biologic agents, and anti-TNF therapy has a protective effect against the development of neurodegenerative diseases in patients with IBD, ranging from AD, PD, and dementia (15, 19, 23, 26, 30, 36–38). This evidence concerns the gene TNF and Alzheimer disease.