In contrast, the high-affinity binding mediated by the anti-CEACAM5 arm induces the co-engagement of CD47 resulting in a “guided inhibition” of the CD47-SIRPα interaction between CD47 on CEACAM5-positive tumor cells and SIRPα on e.g., macrophages and natural killer cells. The gene discussed is SIRPA; the disease is neoplasm.