NILK-2401 induced dose-dependent antibody-dependent cellular cytotoxicity (ADCC) of all CEACAM5-positive tumor cell lines tested (Figure 4A), with EC50 ranging from 0.04 nM (LS174T) to 0.25 nM (SNU-16; Supplementary Table S2). The gene discussed is CEACAM5; the disease is neoplasm.