Never-the-less, key events like the steady infiltration of lymphocytes, including all TCR-, CD4-, and CD8-defined T cell subsets as well as B cells, starting two to three weeks before and reaching maximal levels around vitiligo onset were observed in both studies, attesting to the predictability of autoimmune activities during spontaneous vitiligo development in Smyth chickens. This evidence concerns the gene CD4 and vitiligo.