A high incidence of WT1 overexpression in CBF AML was reported, ranging from 87% up to 100% (p<0.001), while a strong inverse correlation with the presence of KMT2A gene rearrangement (p<0.001) suggesting downregulation of WT1 activating pathway in this leukemia subset, as demonstrated in the present study (1, 9, 20). This evidence concerns the gene KMT2A and leukemia.