Herein, we evaluate the plasma levels of proteins belonging to the IGF signaling system (IGF-2, IGFBP-1, IGFBP-3, IGFBP-5, and IGFBP-7) and inflammatory markers (TNF-α, MCP-1, and MIP-1β) in BD patients who suffered from a manic episode and how the levels of these proteins could be related to the treatment response and the Young Mania Rating Scale (YMRS) (Young et al., 1978) that measures manic episode severity. This evidence concerns the gene TNF and manic or hypomanic episode.