TNF and Behcet disease: A meta-analysis of the available data supports that peripheral TNF-α levels are significantly elevated during manic and depressive episodes but not during euthymia in BD patients (Modabbernia et al., 2013; Munkholm et al., 2018; Rowland et al., 2018; Solmi et al., 2021), suggesting the hypothesis that peripheral inflammation might be dependent on the acute mood state rather than a trait mark in BD.