Despite the fact that most studies were performed on BD patients suffering from a manic episode, no correlation between the YMRS and IGF-1 peripheral levels were found either at baseline (Palomino et al., 2013; Kim et al., 2013; Liu et al., 2014; da Silva et al., 2017) or after treatment (Kim et al., 2013; Palomino et al., 2013). The gene discussed is IGF1; the disease is Behcet disease.