CASP1 and major depressive disorder: Importantly, treatment with RGLS reversed ICV-STZ-induced neuroinflammation, reflected by the normalization of cytokine, NF-κB, NLRP3, caspase-1, and ASC expression in the mPFC, which might be an important mechanism that is related to RGLS-induced improvements in depression- and anxiety-like behaviors (Figure 3).