CNR1 and glioblastoma: As previously mentioned, in this particular context, the growth of glioblastoma cells is effectively inhibited in animal models (mice and rats) by engaging an unambiguous molecular target (CB1R/CB2R) by a family of selective compounds (THC and other cannabinoid receptor agonists) through a defined mode of antitumor action (Rocha et al., 2014; Luís et al., 2020).