Additionally, Zhang et al. [38] found that pancreatic body/tail cancers demonstrated significantly more enriched genomic alterations in KRAS (97.1 % vs. 82.4 %, p = 0.004) and mothers against decapentaplegic homolog 4 (42.0 % vs. 21.2 %, p = 0.008) compared to pancreatic head cancers. The gene discussed is SMAD4; the disease is cancer.