IFNG and melanoma: In a parallel study by Zhang et al. [56], it was demonstrated that elevated expression of IL-2RG, IL-2RA, IL-7R, and IFN-G may assume a pivotal role in driving melanoma metastasis, primarily through the augmentation of intratumoral regulatory T-cell proportions, mainly facilitated by the activation of the JAK-STAT signaling pathway [56].