Principally, our selection of miRNAs with the potential to interact with IL-2RG was initiated based on the literature review, we looked for miRNAs that downregulated in CRC compared to normal tissues and candidate six miRNA including let-7a, miR-7-5p, miR-26b-5p, miR-128, miR-421, and miR-873 [24, 27–29, 35]. The gene discussed is IL2RG; the disease is colorectal carcinoma.