TG and hypothyroidism: Two studies pooled the results of the Institute for Evidence-Based Medicine in Old Age 80-plus thyroid (IEMO80 +) RCT trial (trial number NTR3851) and the Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism (TRUST) RCT trial (trial number NCT01660126) [59, 63].