Lin, for instance, unveiled how FGF21 fosters functional recuperation subsequent to ischemic brain injury via the activation of FGFR1/β-klotho/Akt signaling pathway [35] Furthermore, another investigation substantiated that recombinant FGF21 shields against blood-brain barrier permeability by upregulating Nrf2 in type 2 diabetes mice [36]. This evidence concerns the gene KLB and type 2 diabetes mellitus.